- ISBN 9783642168604 / 3642168604
- Title Extracellular Matrix Degradation
- Category Histology
Cellular Biology (cytology)
- Format Hardcover
- Year 2011
- Pages 300
- Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
- Imprint Springer-Verlag Berlin and Heidelberg GmbH & Co. K
- Language English
- Dimensions 155mm x 235mm x 20mm
This book provides a review of the known classes of proteases that degrade extracellular matrix (ECM) both outside and inside the cell, including cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases.
Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.