Regulatory Networks in Stem Cells

Regulatory Networks in Stem Cells

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This book brings together current advances in embryonic, adult, neural, hematopoietic, mesenchymal and pancreatic stem cell functions. The chapters are authored by top-notch scientists in specialized areas of stem cell biology. Topics of the book focus on: Improved characterization of stem cells, Genomic alterations in stem cells during aging, Differential gene expression profiling during Quiescence, Self renewal and Differentiation, Stem Cell Transcriptomics and Proteomics, Regulatory feed back loops by stem cell transcription factors and post-transcriptional controls, Molecular Signaling Cross-talks in Stem cells, Transcriptional logics behind Nuclear Reprogramming, Clinical perspectives of Emerging Stem cell specific novel small RNAs (Piwi RNAs and MiRNAs), Epigenetic regulation and stem cell specification, and Stem cell niche and its functional significance in therapeutic interventions. The book will be an invaluable resource for researchers, scientists, and clinicians in the rapidly progressing field of stem cells and regenerative medicine.

Publisher Description

Stem cells appear to be fundamental cellular units associated with the origin of multicellular organisms and have evolved to function in safeguarding the cellular homeostasis in organ t- sues. The characteristics of stem cells that distinguish them from other cells have been the fascinating subjects of stem cell research. The important properties of stem cells, such as ma- tenance of quiescence, self-renewal capacity, and differentiation potential, have propelled this exciting ?eld and presently form a common theme of research in developmental biology and medicine. The derivation of pluripotent embryonic stem cells, the prospective identi?cation of multipotent adult stem cells, and, more recently, the induced pluripotent stem cells (popularly called iPS) are important milestones in the arena of stem cell biology. Complex networks of transcription factors, different signaling molecules, and the interaction of genetic and epi- netic events constantly modulate stem cell behavior to evoke programming and reprogramming processes in normal tissue homeostasis during development.
In any given cellular scenario, the regulatory networks can pose considerable complexity and yet exert an orderly control of stem cell differentiation during normal development. An aberration in these ?nely tuned processes during development usually results in a spectrum of diseases such as cancers and neurological disorders. Thisunderscorestheimminentneedforamorecompleteunderstandingofmolecular mechanisms underlying the regulatory circuitries required for stem cell maintenance. Overthepast3-5years,adiversegroupofbenchandphysicianscientistshaveprospectively enhanced our knowledge of stem cell biology. These studies are unveiling many unrecognized or previously unknown fundamentals of developmental biology.

From the reviews: “This volume is an initial attempt to decipher the key factors involved in stem cell pluripotency, maintenance, and directed differentiation toward specific cell lineages and stem cell types. The presentation of the contents is such that upper-grade undergraduates, graduate students, postgraduates, and basic research as well as clinical research scientists are provided with accessible information about recent advances in the stem cell field. The volume consists of 43 comprehensively written chapters divided into five parts ... .” (Anticancer Research, Vol. 29 (11), November, 2009)

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Regulatory Networks in Stem Cells