Coulometric Electrode Array Detectors for HPLC

This volume examines the enhancement of high-performance liquid chromatography through the development of an advanced mode of electrochemical detection (ECD) - the coulometric electrode array - from its initial promising, yet problematic, amperometric (thin-layer) design to the highly sensitive, selective and stable coulometric (flow-through) design. Unlike amperometric electrodes, the coulometric electrode is 100 per cent efficient, and measures signals from all of the analyte passing through it, which leads to improved sensitivity as well as unique selectivity. The coulometric electrode array offers the resolution of the photodiode array with the extreme sensitivity of an electrochemical detector. The book examines the use of the coulometric electrode array, as well as its practical applications in neurosciences, food, environmental, pharmaceutical and agricultural sciences and those in the area of oxidative metabolism. This collection of papers should also provide a useful reference source to all workers in the field of HPLC and those using electrochemical detection.